Molecular Regulation of tumourigenesis by the polarity determinant Scribble and associated proteins

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1004434

Funding Status
Closed

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Funded Activity Summary

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have shown that Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble promotes breast cancer using a combination of tissue culture studies and a newly established mouse model. Understanding how this new pathway can regulate breast tumour development may provide novel targets for therapeutic intervention in cancer.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $614,421.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RAS transformation | cancer biology | cell polarity | epithelial biology | metastatic progression | microenvironment | signalling pathways

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