Somatic gene trapping in Schistosoma mansoni _ the key to functional analysis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1004230

Funding Status
Closed

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Funded Activity Summary

Blood flukes are endemic in 76 countries and infect 300 million people worldwide. Control largely relies on the drug praziquantel. However, its wide scale use has led to concerns that drug resistance will develop. In this study we will use ñgene trap vectorsî to introduce insertional mutations into the schistosome genome. This will help to understand the function and importance of genes in biochemical pathways used by the parasite and to define effective targets for drug and vaccine development.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $623,270.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

functional genomics | gene disruption | intervention | mutagenesis | parasitic disease | schistosomiasis

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