Studying the interaction of Reelin deficiency and environmental factors in the development of schizophrenia using animal behavioural models

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1004129

Funding Status
Closed

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Funded Activity Summary

Schizophrenia is caused by an interaction of genetic predisposition and environmental risk factors such as stress or drug abuse. Reelin is a protein involved in the normal development of the brain but its levels are markedly reduced in schizophrenia. We will use mice with low levels of reelin in their brain and assess the effect of environmental stress and drugs of abuse. These studies could elucidate gene-environment interaction in schizophrenia and lead to new treatment strategies.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $438,695.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

development | dopamine | drug abuse | epigenetics | glutamate receptors | schizophrenia and related disorders | sex differences | stress

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