Can persistent bladder pain be treated by targeting TRPA1 expressing nociceptors?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1003512

Funding Status
Closed

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Funded Activity Summary

Persistent visceral pain is extremely difficult to treat and manage. To solve this problem we need to understand how pain nerves in internal organs differ from those in skin and muscle. We have discovered a pain-detecting molecule TRPA1 in bladder sensory nerves. We aim to show how bladder inflammation changes the function of these bladder pain detectors and test a new way of selectively anesthetising them. We also will use a new technique to study how the bladder lining detects pain.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $687,730.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Peripheral Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

electrophysiology | inflammatory diseases | neurogenic inflammation | pain | pain mechanisms | pharmacology | urinary bladder | visceral afferents

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