Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1003326

Funding Status
Closed

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Funded Activity Summary

Humans first detect the presence of pathogens and respond to them through specific pathways termed innate immune pathways. The proposed research will study proteins that participate in these pathways, in particular their three-dimensional structures and how they interact with each other, to understand how they work together to mount an immune response, and to find ways to modulate this response in infectious diseases as well as chronic inflammatory diseases.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $666,417.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Toll-like receptors | inflammatory diseases | innate immunity | peptide inhibitors | protein-protein interaction | structural biology | structural immunology

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