RNA Polymerase I: A novel target in the treatment of MYC driven malignancies

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1003270

Funding Status
Closed

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Funded Activity Summary

Synthesis of ribosomes, the cellular protein synthetic machinery, is dysregulated during cancer leading to the hypothesis that it may be causative in the malignant process. This application will test this hypothesis using novel inhibitors or ribosome biogenesis in a mouse genetic model termed E�-MYC that faithfully that replicates human B-cell lymphoma. These studies will uncover novel mechanisms in malignant transformation and identify new therapeutics in the treatment of human cancer.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $605,963.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B cells | apoptosis | cancer cell biology | cancer chemotherapeutic agents | cancer research | haematological malignancy | leukaemia | lymphoma | transcriptional regulation

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