Subcellular trafficking of P proteins of human pathogenic viruses: roles in viral pathogenicity and targeting for therapeutics

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1003244

Funding Status
Closed

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Funded Activity Summary

In order to infect humans, pathogenic viruses such as rabies, Nipah, Hendra and Australian bat lyssavirus must be able to evade the immune response. To do this, viruses produce "interferon antagonists" that interfere with specific immune processes by mechanisms that are not fully understood. Our study will characterise the mechanisms used by rabies and other viruses to block immunity, and identify strategies to disable viral immune evasion, rendering these lethal viruses susceptible to destruction by the human immune system.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $578,352.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

immune evasion | innate immunity | nuclear import | vaccine design | viral infection | viral proteins | virus pathogenesis

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