Preventing myocardial infarction: A mouse model of atherosclerotic plaque instability/rupture as unique tool for establishing novel pharmacological strategies and targeted molecular imaging

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1003234

Funding Status
Closed

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Funded Activity Summary

Myocardial infarction strikes without warning and thereby causes death or major disability. It is typically caused by sudden rupture of atherosclerotic plaques and occlusion of coronary arteries. Research on this was hampered by the lack of an animal model of plaque rupture. We have newly established a mouse model, which we will now use to generate novel tools to image and identify plaques that are prone to rupture and to develop novel therapies preventing plaque rupture and myocardial infarction.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $586,965.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acute coronary syndromes | atherosclerosis | expression profiling | inflammation | myocardial infarction | plaque rupture | stroke | sudden cardiac death | thrombosis

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