Unravelling the mechanisms by which insulin hypersecretion is detrimental to ß-cell function and survival in Type 2 diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1002902

Funding Status
Closed

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Funded Activity Summary

Type 2 diabetes is associated with reduced levels of the hormone insulin that results in an increase in blood sugar. Evidence suggests that when the cells that make insulin are overworked they fail to produce the right amount of this hormone to keep blood sugar levels normal. In this proposal we will determine how overworking the insulin producing cells damages them and assess whether reducing the need to overwork is beneficial and thus lead to reduced blood sugar levels in Type 2 diabetes.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2016

Funding Scheme: Research Fellowships

Funding Amount: $727,758.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

carbohydrate metabolism | cell metabolism | diabetes | dietary fat | insulin secretion | islets of Langerhans | obesity | transgenic model

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