Regulation of hypothalamic insulin & leptin signalling by TCPTP

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1002709

Funding Status
Closed

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Funded Activity Summary

Insulin & leptin signal in the brain to lower blood glucose, suppress food intake, increase activity & increase energy expenditure. Obesity diminishes the abilities of insulin & leptin to signal. This proposal will determine if the enzyme TCPTP terminates insulin & leptin signaling in the brain. Our studies will provide insight into the molecular causes of obesity & may identify a novel therapeutic target for the treatment of obesity & type 2 diabetes.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $758,504.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell signalling | diabetes mellitus | endocrinology | insulin sensitivity | leptin | obesity | protein tyrosine phosphatase (PTP)

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