How do p75 and sortilin facilitate TrkA-mediated survival signalling?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1002610

Funding Status
Closed

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Funded Activity Summary

Neurotrophins are the classical growth factors that regulate neuronal survival and death throughout the nervous system in both the developing and adult animal. These factors signal through one of three receptors, but precisely how the receptors interact to propagate cell survival is unclear. The goal of this grant is to unravel the molecular basis underpinning this life and death signalling decision so that we can then devise ways to promote cell survival in neurodegenerative conditions

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $559,354.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

apoptosis of neurons | developmental biology | disease mechanisms | neurodegeneration | neurotrophins | receptor dimerisation | receptor signalling | receptor trafficking

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