DHPR ? subunit binding to a variably spliced region of RyR1: a role in EC coupling and myotonic dystrophy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1002589

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

We have uncovered a communication pathway between two ion channel molecules in muscle cells that underlies human movement. The pathway is critical in normal mobility and is disrupted in myotonic dystrophy. We will study the molecular components of this pathway to understand normal body function and abnormal function in mytotonic dystrophy. The work will facilitate the design of drugs to relieve the mytotonic dystrophy myopathy and form new and much needed class of specific muscle relaxants.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $555,892.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Peripheral Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

excitation-contraction coupling | muscle contraction | muscle disease | muscle function | myopathy | myotonic dystrophy | neuromuscular diseases | ryanodine receptor (RyR) | skeletal muscle

Related Links