Defining the leukaemogenic mechanism for GATA2 T354M, a new predisposing mutation in familial MDS/AML

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1002317

Funding Status
Closed

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Funded Activity Summary

A successful approach for identification of cancer genes has been to study the 5-10% of cases occurring in families with inherited predisposition to develop cancer. Unlike solid tumours, few cancer-causing mutations are known for haematological cancers. We have found a new mutation in 3 families in a gene (GATA2) not previously associated with familial acute myeloid leukaemia. We will explore how this mutation causes leukaemia to help better understand the more common non-inherited leukaemias.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $631,883.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

genetic predisposition | haematological malignancy | haematopoiesis | inherited | leukaemia | molecular genetics | mutation analysis | myelopoiesis | transcription factor

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