The influence of a-actinin-3 on muscle structure, metabolism, performance and response to diet and disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1002033

Funding Status
Closed

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Funded Activity Summary

We have identified a common genetic variant that results in absence of the fast muscle fibre protein a-actinin-3 in more than one billion humans worldwide. Loss of a-actinin-3 influences elite athletic performance, muscle bulk and strength in the general population, response to diet and exercise, and susceptibility to developing type 2 diabetes. We will now study mice and humans to determine how this gene influences variations in human performance, metabolism and severity of muscle disease.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $624,355.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetics not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

diabetes | gene function | genetic predisposition | muscle damage | muscle disease | muscle function | muscular dystrophy | myopathy | transgenic mouse | weight disorders

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