Development of a new high throughput screen for drug binding to hERG K+ channels

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1000587

Funding Status
Closed

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Funded Activity Summary

Inadvertent drug block of hERG, a potassium channel in the heart, can cause cardiac arrhythmias and sudden cardiac death. Screening for hERG toxicity has become a major hurdle for development of new drugs. We will use a mutant hERG protein that has enhanced drug binding to develop a high throughput test for hERG toxicity. Identification of dangerous drugs early in the drug discovery process will save the pharmaceutical industry millions of dollars in the costs of brining new drugs to market.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Development Grants

Funding Amount: $351,320.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Toxicology (incl. Clinical Toxicology)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arrhythmia | drug development | drug screening | drug toxicity | ion channels | pharmacology

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