Linkage - International - Grant ID: LX0882427

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LX0882427

Funding Status
Closed

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Funded Activity Summary

Membrane excitability and cellular calcium regulation in the peripheral nervous system under different (patho)-physiological conditions and in inflammatory disease. Studies of cytokine action on neurons and muscle give new insights into functional responses of the nervous system to systemic inflammation and sepsis. In some countries, sepsis is the third most frequent cause of death following heart attack. Elucidating the pathomechanisms allows to develop therapeutic strategies. Electrophysiology, Ca2+ regulation and optical membrane potentiometry allow us to monitor early changes in disease on a (sub)cellular level. Experiments on Ca2+ regulation and ion channel function in muscle with different cholesterol membrane contents will help to understand pathomechanisms in high cholesterol diseases, e.g. obesity, on the membrane level long before cardiovascular effects become prominent.

Funded Activity Details

Start Date: 01-01-2008

End Date: 31-12-2008

Funding Scheme: Linkage - International

Funding Amount: $131,306.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Peripheral Nervous System | Cell Physiology | Membrane Biology | Neurosciences

ANZSRC Socio-Economic Objective (SEO)

Immune system and allergy | Public health not elsewhere classified | Nervous system and disorders |

Other Keywords

Cell Physiology | Immune system and allergy | Membrane Biology | Nervous system and disorders | Neurosciences | Peripheral Nervous System | Public health not elsewhere classified

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