Linkage - International - Grant ID: LX0776107

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LX0776107

Funding Status
Closed

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Funded Activity Summary

Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy (the pyridine-2-carboxaldehyde isonicotinoyl hydrazone [PCIH] analogues) which show oral activity. These chelators undergo some interesting iron catalysed oxidation chemistry and it is vital that the mechanism of this reaction be elucidated to determine whether it will be of biological significance upon administration of these compounds as iron chelators.

Funded Activity Details

Start Date: 01-01-2007

End Date: 30-04-2010

Funding Scheme: Linkage - International

Funding Amount: $12,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Bioinorganic Chemistry | Inorganic Chemistry | Transition Metal Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Chemical sciences

Other Keywords

Bioinorganic Chemistry | Chemical sciences | Inorganic Chemistry | Transition Metal Chemistry

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