Linkage - International - Grant ID: LX0345638

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LX0345638

Funding Status
Closed

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Funded Activity Summary

Development of metal probes for the selective recognition of DNA. Transition metal complexes with large aromatic ligands have recently been shown to bind DNA by intercalation. However, controversy continues over their base sequence and groove selectivity. We will synthesise a range of chiral metal complexes and screen these against combinatorial oligonucleotide libraries to determine their base sequence selectivity. The information obtained will help us design better intercalators that can be used as sensitive molecular probes and may find application as antitumour drugs. Binding interaction between the complex and DNA will be studied by NMR spectroscopy.

Funded Activity Details

Start Date: 01-01-2003

End Date: 28-02-2004

Funding Scheme: Linkage - International

Funding Amount: $74,377.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Chemistry | Bioinorganic Chemistry | Medicinal and Biomolecular Chemistry | Biological And Medical Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Chemical sciences

Other Keywords

Bioinorganic Chemistry | Biological And Medical Chemistry | Chemical sciences | Medicinal and Biomolecular Chemistry | Structural Chemistry

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