Linkage - International - Grant ID: LX0211971

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LX0211971

Funding Status
Closed

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Funded Activity Summary

Crystallographic studies of aldose and aldehyde reductases. The ability of aldose reductase to reduce the excess glucose that results from the hyperglycaemia of diabetes has been linked to the development of diabetic complications. Recent studies link the lack of a clinically suitable aldose reductase inhibitor to lack of inhibitor selectivity. The structures of the complexes of aldose and aldehyde reductases with various inhibitors should allow us to establish the important aspects of the inhibitor interaction with the residues of the active site. This information will be used in the design of more specific aldose reductase inhibitors.

Funded Activity Details

Start Date: 01-01-2002

End Date: 31-12-2005

Funding Scheme: Linkage - International

Funding Amount: $60,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Biological And Medical Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Endocrine organs and diseases (incl. diabetes) | Treatments (e.g. chemicals, antibiotics) | Biological sciences

Other Keywords

Biochemistry and Cell Biology | Biological And Medical Chemistry | Biological sciences | Endocrine organs and diseases (incl. diabetes) | Enzymes | Treatments (e.g. chemicals, antibiotics)

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