Linkage Projects - Grant ID: LP210200908

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP210200908

Funding Status
Active

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Funded Activity Summary

Developing macrophage-based technologies for tissue regeneration. Different tissues show distinct regenerative capacities with an organism and across the phylogeny. What underlies this diversity in regenerative ability at cellular and molecular level is far from clear. Building on foundational discoveries in zebrafish, this study seeks to determine if this capacity could, in part, be explained through the properties of a component of the innate immune system, the macrophage, which preliminary data shows generates a transient pro-regenerative muscle stem cell niche in zebrafish. This study will determine if macrophage subtypes acts to coordinate regeneration in other tissues and systems and if a programable pro-regenerative cell can be made in vitro that stimulate regeneration in different settings.

Funded Activity Details

Start Date: 03-03-2023

End Date: 02-03-2026

Funding Scheme: Linkage Projects

Funding Amount: $857,800.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

Veterinary Pharmaceutical Products not elsewhere classified | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified | Expanding Knowledge in the Biological Sciences | Veterinary Pharmaceutical Products not elsewhere classified

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