Linkage Projects - Grant ID: LP190101290

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP190101290

Funding Status
Active

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Funded Activity Summary

Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cells, termed the Lymphocyte activation gene-3 (LAG-3). The proposal utilises a combination of cellular immunology and structural biology to gain insight into the form and function of the LAG-3 molecule. Ultimately this fundamental knowledge can be used by the biotechnology industry.

Funded Activity Details

Start Date: 27-08-2020

End Date: 26-08-2023

Funding Scheme: Linkage Projects

Funding Amount: $671,427.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Tumour Immunology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy |

Other Keywords

Autoimmunity | Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Structural Biology (incl. Macromolecular Modelling) | Tumour Immunology

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