Linkage Projects - Grant ID: LP180100560

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP180100560

Funding Status
Active

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Funded Activity Summary

Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project outcomes are intended to lead to significant advances in membrane protein structure determination and will have a substantial impact on future research in the pharmaceutical industry.

Funded Activity Details

Start Date: 09-10-2019

End Date: 12-12-2022

Funding Scheme: Linkage Projects

Funding Amount: $464,233.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biomolecular Modelling and Design | Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Nervous System and Disorders | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Biochemistry and Cell Biology | Biomolecular Modelling and Design | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Nervous System and Disorders | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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