Linkage Projects - Grant ID: LP180100540

Funded Activity Summary

Engineering a physiologically-relevant blood vessel in vitro . The project will develop an in vitro blood vessel model which will mimic arterial conditions by incorporating vascular cells and silk conduits as scaffolds, for the first time. This approach will overcome the limitations of simplistic 2D cell cultures, the long maturation times of fully tissue-engineered vessels, and resource intensive animal models. The innovative bioengineered construct proposed builds on the CI’s significant advances in materials and surface engineering and the Partner Organisation’s (Codex Research) new bioreactor platform. It will offer a solution for modelling of native vessel processes in vitro that would be more appropriate for pre-clinical drug and device development, and in the long-term, tissue replacement.

Funded Activity Details

Start Date: 01-01-2019

End Date: 31-12-2022

Funding Scheme: Linkage Projects

Funding Amount: $520,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Functional Materials | Biomechanical Engineering | Biomedical Engineering |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Biomechanical Engineering | Biomedical Engineering | Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Functional Materials

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