Linkage Projects - Grant ID: LP170101085

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP170101085

Funding Status
Active

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Funded Activity Summary

Novel chemoenzymatic synthesis and bioconjugation of peptides and proteins. This project aims to solve the critical difficulty of producing the complex peptide insulin and related insulin-like peptides (INSLs) and their analogues. The project will use unique, recyclable enzymes which ligate smaller peptide segments with extraordinary site and substrate selectivity. The expected outcome of the project is novel, cheaper and scalable, enzyme-mediated engineering of this critical class of peptides as biological probes and potential therapeutic agents.

Funded Activity Details

Start Date: 21-06-2019

End Date: 31-12-2023

Funding Scheme: Linkage Projects

Funding Amount: $619,727.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Biocatalysis and Enzyme Technology | Medicinal and Biomolecular Chemistry | Medicinal and Biomolecular Chemistry not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Products not elsewhere classified | Human Pharmaceutical Treatments (e.g. Antibiotics) |

Other Keywords

Biocatalysis and Enzyme Technology | Human Pharmaceutical Products not elsewhere classified | Human Pharmaceutical Treatments (e.g. Antibiotics) | Medicinal and Biomolecular Chemistry | Medicinal and Biomolecular Chemistry not elsewhere classified | Proteins and Peptides

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