Linkage Projects - Grant ID: LP160101373

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP160101373

Funding Status
Closed

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Funded Activity Summary

The cell biology of the albumin-FcRn receptor recycling system. The aim of this project is to define the cell biology of the albumin-FcRn (neonatal Fc receptor) recycling system. FcRn is a recycling membrane receptor that selectively protects serum proteins from intracellular degradation and prolongs their half-life. We will identify the key cell types involved in this recycling pathway, identify intracellular sites of ligand and FcRn interaction, assess the contribution of the haematopoietic system and determine ligand half-life in mice. Findings generated will reveal the basic biology of an important physiological receptor, and enable the exploitation of FcRn-receptor interactions for design of recombinant albumin fusion-based therapies.

Funded Activity Details

Start Date: 19-09-2017

End Date: 31-12-2021

Funding Scheme: Linkage Projects

Funding Amount: $470,473.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking | Biochemistry and Cell Biology | Receptors and Membrane Biology | Medical Molecular Engineering of Nucleic Acids and Proteins |

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Products not elsewhere classified | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in Technology

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in Technology | Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Products not elsewhere classified | Medical Molecular Engineering of Nucleic Acids and Proteins | Protein Trafficking | Receptors and Membrane Biology

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