Linkage Projects - Grant ID: LP160100979

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP160100979

Funding Status
Closed

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Funded Activity Summary

Modulating T cell responses with novel Lck activating compounds. Modulating T cell responses with novel Lck activating compounds. This project aims to research T cell receptor (TCR) signal initiation and network plasticity and identify uses for drugs that affect the kinase Lck. The TCR signalling network has considerable plasticity so that modulation of one molecule (here the drug target is Lck) can have non-linear effects on T cell function. This project intends to use novel drugs to understand how the T cell network can be exploited to control both the magnitude and quality of the T cell responses. This research is expected to aid the design of immune-modulating drugs.

Funded Activity Details

Start Date: 24-10-2016

End Date: 31-12-2020

Funding Scheme: Linkage Projects

Funding Amount: $335,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Receptors and Membrane Biology | Signal Transduction |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Receptors and Membrane Biology | Signal Transduction

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