Linkage Projects - Grant ID: LP160100786

Funded Activity Summary

Understanding and modelling platelet flow and binding in blood. Understanding and modelling platelet flow and binding in blood. This project aims to predict how platelets flow through vascular scale geometries, using an experimental and numerical development programme. Platelets maintain a healthy vascular system. Like other cells, they respond to local stimuli: the concentration of chemical agonists, bonds with neighbouring species, fluid dynamic stresses, and even their history. On a single cell level, many of these biophysical processes are not understood or quantified. At the blood vessel level, multiscale modelling techniques cannot translate this single cell knowledge to capture how collections of platelets behave. This project is expected to lead to better therapies for cardiovascular disease and a new class of strongly interacting multiphase fluid dynamics problems.

Funded Activity Details

Start Date: 15-12-2016

End Date: 15-12-2021

Funding Scheme: Linkage Projects

Funding Amount: $420,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Interdisciplinary Engineering | Biochemistry and Cell Biology not elsewhere classified | Computational Fluid Dynamics | Biological Physics

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Products not elsewhere classified | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Biochemistry and Cell Biology not elsewhere classified | Biological Physics | Computational Fluid Dynamics | Expanding Knowledge in the Medical and Health Sciences | Human Pharmaceutical Products not elsewhere classified | Interdisciplinary Engineering

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