Linkage Projects - Grant ID: LP160100560

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP160100560

Funding Status
Closed

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Funded Activity Summary

Engineered extrasynaptic GABAA receptors: Towards novel analgesics. Engineered extrasynaptic GABAA receptors: Towards novel analgesics. This project intends to alleviate neuropathic pain by developing drugs and good tool molecules targeting GABA-A receptors. About 20% of Australian adults suffer from neuropathic pain. Delta-containing GABA-A receptors represent attractive and novel targets for developing non-opioid analgesics. However, no drugs or good tool molecules target these receptors. This project intends to develop the needed enabling technologies, including screening assays, tool molecules and radioligands; and perform brain slice electrophysiology to confirm activity in neuronal cells. This project is expected to benefit the research community and future rational drug-discovery endeavours for drugs that modulate delta-containing receptors.

Funded Activity Details

Start Date: 01-05-2017

End Date: 31-12-2020

Funding Scheme: Linkage Projects

Funding Amount: $525,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmaceutical Sciences | Medicinal and Biomolecular Chemistry | Biomolecular Modelling and Design | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Nervous System and Disorders | Mental Health |

Other Keywords

Biologically Active Molecules | Biomolecular Modelling and Design | Medicinal and Biomolecular Chemistry | Mental Health | Nervous System and Disorders | Pharmaceutical Sciences

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