Linkage Projects - Grant ID: LP150100308

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP150100308

Funding Status
Closed

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Funded Activity Summary

Synthesis and Structure-Function Studies of the Glycoprotein Adiponectin. This project aims to understand the role of carbohydrate modifications on the structure and function of the fat cell-derived hormone adiponectin, which has shown protective effects against obesity, type 2 diabetes and cardiovascular disease. Advancing knowledge of the molecular mechanisms that regulate fat is crucial to unravelling the processes involved in the development of these diseases. The project plans to use novel synthetic technologies to access a library of adiponectins with defined patterns of carbohydrates attached to the peptide backbone, thus potentially enabling detailed dissection of the role of these modifications on structure, cell signalling and insulin sensitising activities.

Funded Activity Details

Start Date: 01-02-2016

End Date: 01-02-2019

Funding Scheme: Linkage Projects

Funding Amount: $305,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Organic Chemistry | Organic Chemical Synthesis | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Diabetes | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biologically Active Molecules | Diabetes | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Organic Chemical Synthesis | Organic Chemistry | Proteins and Peptides

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