Linkage Projects - Grant ID: LP150100137

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP150100137

Funding Status
Closed

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Funded Activity Summary

Novel antimicrobial target discovery by an integrated approach. The project aims to uncover the molecular targets of BDM-I, a novel antimicrobial candidate discovered by the start-up Australian company BioDiem Ltd. BDM-I is active against many drug resistant bacterial and fungal microorganisms and it is currently in pre-clinical development. However, the lack of resistant phenotypes makes it difficult to identify BDM-I’s mechanism of action. The project plans to use an integrated approach that combines a novel technique of in silico screening with experimental validation. Project outcomes are anticipated to include the first computational method to integrate target and ligand similarity for proteome-scale target and off-target discovery, which will advance the global fight against drug-resistant microorganisms.

Funded Activity Details

Start Date: 28-09-2016

End Date: 31-12-2018

Funding Scheme: Linkage Projects

Funding Amount: $241,564.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Analytical Biochemistry | Bioinformatics

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Products not elsewhere classified | Expanding Knowledge in the Biological Sciences |

Other Keywords

Analytical Biochemistry | Biochemistry and Cell Biology | Bioinformatics | Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Products not elsewhere classified

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