Linkage Projects - Grant ID: LP150100087

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP150100087

Funding Status
Closed

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Funded Activity Summary

Improving clostridial toxoid production through molecular fermentation maps. This project aims to improve vaccine production by generating detailed molecular maps of fermentation which will be used to design superior fermentation processes with reduced cost. Toxoid vaccines, used routinely in the livestock industry to prevent animal-disease caused by pathogenic Clostridia, are produced using batch fermentation processes. These processes have undergone limited optimisation over the past five decades. Low titres and frequent batch failures greatly affect capital use and represent a significant cost. In addition, current optimisation approaches are limited by the use of expensive and noisy endpoint assays. This project aims to use high-throughput chemistry (multi-omics) that overcome these limitations.

Funded Activity Details

Start Date: 16-05-2016

End Date: 31-12-2019

Funding Scheme: Linkage Projects

Funding Amount: $488,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Industrial Microbiology (incl. Biofeedstocks) | Systems Biology

ANZSRC Socio-Economic Objective (SEO)

Veterinary Biological Preventatives (e.g. Vaccines) |

Other Keywords

Biochemistry and Cell Biology | Industrial Microbiology (incl. Biofeedstocks) | Systems Biology | Veterinary Biological Preventatives (e.g. Vaccines)

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