Linkage Projects - Grant ID: LP140100798

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP140100798

Funding Status
Closed

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Funded Activity Summary

Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.

Funded Activity Details

Start Date: 01-07-2014

End Date: 14-01-2018

Funding Scheme: Linkage Projects

Funding Amount: $546,420.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) | Biomedical Engineering not elsewhere classified | Medical Biochemistry and Metabolomics |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Biomedical Engineering not elsewhere classified | Expanding Knowledge in Engineering | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Medical Biochemistry and Metabolomics | Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) | Proteomics and Intermolecular Interactions (excl. Medical Proteomics)

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