Linkage Projects - Grant ID: LP140100781

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP140100781

Funding Status
Closed

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Funded Activity Summary

Pharmacological probes to facilitate preclinical development of modulators of a6 subunit containing nicotinic acetylcholine receptors. Allosteric modulators of alpha7 nicotinic acetylcholine receptors have a promising future as drugs targeting attention deficits in Alzheimer’s disease and schizophrenia but the mechanisms underlying modulation are poorly understood. This project aims to determine its binding site and develop a radioactive labelled compound that competes with its binding. The radiolabelled compound and a deeper insight into the mode of action will enable development of ligands for positron emission tomography (PET) which will aid in the development of BNC375 as well as other alpha7 modulators.

Funded Activity Details

Start Date: 01-01-2015

End Date: 30-10-2017

Funding Scheme: Linkage Projects

Funding Amount: $250,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences | Basic Pharmacology | Receptors and Membrane Biology | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Diagnostic Methods | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Basic Pharmacology | Biologically Active Molecules | Diagnostic Methods | Expanding Knowledge in the Medical and Health Sciences | Pharmacology and Pharmaceutical Sciences | Receptors and Membrane Biology

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