Linkage Projects - Grant ID: LP140100377

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP140100377

Funding Status
Closed

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Funded Activity Summary

Perturbation of the extracellular architecture to promote the absorption and lymphatic transport of biological macromolecules. Macromolecules therapeutics such as proteins, antibodies or polymer conjugates pose a number of pharmaceutical challenges. Where the dose is high, drainage of that dose from a subcutaneous injection site into the circulation, poses a particular problem. Here the project aims to explore how recombinant hyaluronidase, an enzyme that breaks down a structural component (hyaluronan) of the interstitum, can be used promote absorption into the draining blood and lymph capillaries. The project aims to also explore the downstream effects of hyaluronidase on lymph nodes and evaluate whether the enzyme is able to temporarily disrupt the lymph node structure and promote drug penetration into the lymph node mass. This has significant potential for improved drug targeting.

Funded Activity Details

Start Date: 06-01-2015

End Date: 31-12-2018

Funding Scheme: Linkage Projects

Funding Amount: $409,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences | Pharmaceutical Sciences |

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Treatments (e.g. Antibiotics)

Other Keywords

Human Pharmaceutical Treatments (e.g. Antibiotics) | Pharmaceutical Sciences | Pharmacology and Pharmaceutical Sciences

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