Linkage Projects - Grant ID: LP0990498

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0990498

Funding Status
Closed

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Funded Activity Summary

Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic. The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will exploit two sophisticated new synthetic techniques for the purposes of making analogues of platencin that will be screened by the industry partner, Biota, for anti-bacterial properties. New drug candidates capable of treating especially dangerous infections such as methicillin resistant staphyllococcus aureus (MRSA) should thus emerge.

Funded Activity Details

Start Date: 01-10-2010

End Date: 24-04-2014

Funding Scheme: Linkage Projects

Funding Amount: $283,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Organic Chemistry | Biological And Medical Chemistry | Organic Chemical Synthesis |

ANZSRC Socio-Economic Objective (SEO)

Respiratory system and diseases (incl. asthma) | Prevention—biologicals (e.g. vaccines) | Treatments (e.g. chemicals, antibiotics)

Other Keywords

Biological And Medical Chemistry | Organic Chemical Synthesis | Organic Chemistry | Prevention—biologicals (e.g. vaccines) | Respiratory system and diseases (incl. asthma) | Treatments (e.g. chemicals, antibiotics)

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