Linkage Projects - Grant ID: LP0562660

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0562660

Funding Status
Closed

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Funded Activity Summary

Synthesis and evaluation of anti-microbial porphyrin adducts for the targeted inhibition of Porphyromonas gingivalis. At present the effectiveness of therapy for inflammatory disease of the gum tissue (periodontitis) is limited by the lack of a selective anti-microbial agent. The investigators have discovered a novel mechanism of binding of the blood product porphyrin by a unique receptor of a key pathogen implicated in this disease. By exploiting this knowledge a modified porphyrin linked to an antibiotic was shown to have a selective effect on the target organism. Refinement of this complex has the potential to provide a clinically useful, selective agent.

Funded Activity Details

Start Date: 21-01-2006

End Date: 13-07-2010

Funding Scheme: Linkage Projects

Funding Amount: $285,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Organic Chemistry | Biological And Medical Chemistry | Organic Chemical Synthesis |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Treatments (e.g. chemicals, antibiotics)

Other Keywords

Biological And Medical Chemistry | Organic Chemical Synthesis | Organic Chemistry | Treatments (e.g. chemicals, antibiotics)

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