Linkage Projects - Grant ID: LP0562243

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0562243

Funding Status
Closed

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Funded Activity Summary

The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present an opportunity to control hypertension whilst simultaneously limiting fibrosis in the kidney. Renal failure is steadily increasing and is now the single largest health care cost to the community. These studies will provide the proof of concept required to ultimately bring this novel preventative therapy to the community.

Funded Activity Details

Start Date: 23-03-2006

End Date: 22-03-2008

Funding Scheme: Linkage Projects

Funding Amount: $110,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical Sciences | Endocrinology | Cardiology (Incl. Cardiovascular Diseases) | Nephrology And Urology

ANZSRC Socio-Economic Objective (SEO)

Urogenital system and disorders | Endocrine organs and diseases (incl. diabetes) | Treatments (e.g. chemicals, antibiotics) |

Other Keywords

Cardiology (Incl. Cardiovascular Diseases) | Clinical Sciences | Endocrine organs and diseases (incl. diabetes) | Endocrinology | Nephrology And Urology | Treatments (e.g. chemicals, antibiotics) | Urogenital system and disorders

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