Linkage Projects - Grant ID: LP0562041

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0562041

Funding Status
Closed

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Funded Activity Summary

Theoretical studies of molecular mechanisms of abnormal protein aggregation. Many proteins undergo conformational change and association as part of their physiological behavior. However, some proteins share a tendency to abnormal aggregation and form amyloid fibrils leading to disorders such as Alzheimer's and variant Creutzfeldt-Jacob diseases. Insulin, one such protein, has a high propensity to aggregate and form fibrils creating difficulties in preparation, storage and application. Using advanced theoretical modelling techniques we will gain insight into the molecular mechanism of fibrillation by investigating the formation of insulin aggregates. An improved understanding of the essential mechanism of protein aggregation will allow the rational design of new drugs.

Funded Activity Details

Start Date: 23-09-2005

End Date: 01-07-2009

Funding Scheme: Linkage Projects

Funding Amount: $215,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Theoretical And Computational Chemistry Not Elsewhere Classified | Biological And Medical Chemistry | Macromolecular and Materials Chemistry | Physical Chemistry Of Macromolecules

ANZSRC Socio-Economic Objective (SEO)

Health related to ageing | Prevention—biologicals (e.g. vaccines) | Organs, diseases and abnormal conditions not elsewhere classified |

Other Keywords

Biological And Medical Chemistry | Health related to ageing | Macromolecular and Materials Chemistry | Organs, diseases and abnormal conditions not elsewhere classified | Physical Chemistry Of Macromolecules | Prevention—biologicals (e.g. vaccines) | Theoretical And Computational Chemistry Not Elsewhere Classified

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