Linkage Projects - Grant ID: LP0561957

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0561957

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Application of in vivo electroporation to DNA immunisation. The in vivo delivery of plasmid DNA induces immune responses to the encoded protein vaccine. In large animals including humans, DNA vaccination needs to be further improved before becoming a commercial reality, at least partially due to the very low levels of expression in vivo. In vivo electroporation has proven to be an effective way to enhance the level of protein expression and increase DNA vaccine efficacy. We combine enhanced in vivo expression using electroporation with the co-delivery of plasmids encoding cytokines to enhance and modulate DNA vaccine in sheep. We will apply our findings to bovine viral diarrhoea virus (BVDV), both as an animal model for humans and as an economically important diseases of livestock.

Funded Activity Details

Start Date: 15-02-2006

End Date: 31-12-2008

Funding Scheme: Linkage Projects

Funding Amount: $405,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Veterinary Sciences | Animal Protection (Pests And Pathogens) | Immunology | Immunology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

Veterinary pharmaceutical products | Sheep—meat | Prevention—biologicals (e.g. vaccines) |

Other Keywords

Animal Protection (Pests And Pathogens) | Immunology | Immunology Not Elsewhere Classified | Prevention—biologicals (e.g. vaccines) | Sheep—meat | Veterinary Sciences | Veterinary pharmaceutical products

Related Links