Linkage Projects - Grant ID: LP0560931

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0560931

Funding Status
Closed

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Funded Activity Summary

Covalent Hydrogen Bond Mimetics of Helical Peptide Hormones. Peptide hormones have been identified that adopt a helical shape when bound to their receptor. The project will produce new versions of these hormones by the use of directly bonded chemical linkers in place of the relatively weak helix hydrogen bonds. The resulting hormone mimics will be more stable, have lower molecular weight and be more selective than the natural hormones making them more suitable as drugs. Our new chemical techniques allow us for the first time to fully investigate this approach which if successful will be applicable to many other helical peptides and therefore could be an important drug development technique.

Funded Activity Details

Start Date: 01-01-2005

End Date: 31-12-2007

Funding Scheme: Linkage Projects

Funding Amount: $225,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Organic Chemistry | Biological And Medical Chemistry | Organic Chemical Synthesis | Protein Targeting And Signal Transduction |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences | Chemical sciences

Other Keywords

Biological And Medical Chemistry | Biological sciences | Chemical sciences | Organic Chemical Synthesis | Organic Chemistry | Protein Targeting And Signal Transduction | Treatments (e.g. chemicals, antibiotics)

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