Linkage Projects - Grant ID: LP0560652

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0560652

Funding Status
Closed

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Funded Activity Summary

Studies on the stereospecific interaction between aldose reductase and inhibitor. There is no therapy specific for treatment of diabetes complications accepted worldwide. The enzyme aldose reductase has shown promising results as a drug target for preventing or delaying the onset of the complications. The structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat will be determined at high resolution in order to elucidate the binding modes responsible for the differences in their inhibitory potencies. The results may lead to the design of better inhibitors of the enzyme for the treatment of diabetes sufferers, at least until better methods for maintaining metabolic control are developed.

Funded Activity Details

Start Date: 01-01-2005

End Date: 31-12-2006

Funding Scheme: Linkage Projects

Funding Amount: $85,814.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Biological And Medical Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Endocrine organs and diseases (incl. diabetes) | Treatments (e.g. chemicals, antibiotics) | Biological sciences

Other Keywords

Biochemistry and Cell Biology | Biological And Medical Chemistry | Biological sciences | Endocrine organs and diseases (incl. diabetes) | Enzymes | Treatments (e.g. chemicals, antibiotics)

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