Linkage Projects - Grant ID: LP0560595

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0560595

Funding Status
Closed

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Funded Activity Summary

BIOCATALYSTS MINED FROM CYTOCHROME P450 LIBRARIES: AN INNOVATIVE TOOL FOR ACCELERATING DRUG DEVELOPMENT. The cytochrome P450s (P450s) are a family of enzymes that are perhaps the most versatile biological catalysts known. DNA shuffling is an emerging technique that takes the genes encoding families of enzymes and creates libraries of catalysts with both improved and novel properties. We will obtain proof of concept that shuffled P450 libraries can be screened and optimized for use as biocatalysts in drug development. The methodologies developed here will overcome two critical bottlenecks in current drug development: the optimisation and metabolic profiling of new drug candidates. This will yield important benefits in accelerating the optimisation and safety testing of drugs under development.

Funded Activity Details

Start Date: 11-07-2005

End Date: 10-07-2008

Funding Scheme: Linkage Projects

Funding Amount: $461,454.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Agricultural Biotechnology | Enzymes | Genetic Engineering And Enzyme Technology | Pharmaceutical Sciences And Pharmacy |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences

Other Keywords

Agricultural Biotechnology | Biological sciences | Enzymes | Genetic Engineering And Enzyme Technology | Pharmaceutical Sciences And Pharmacy | Treatments (e.g. chemicals, antibiotics)

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