Linkage Projects - Grant ID: LP0560289

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0560289

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on challenge of cells with LPS, while increasing the levels of the anti-inflammatory cytokine IL-10. Investigating the role of Cpn10 in modulating inflammation will contribute to the understanding and treatment of diseases associated with inflammation, including multiple sclerosis and rheumatoid arthritis.

Funded Activity Details

Start Date: 01-01-2005

End Date: 31-12-2010

Funding Scheme: Linkage Projects

Funding Amount: $337,826.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Proteins And Peptides | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Immune system and allergy |

Other Keywords

Biochemistry and Cell Biology | Immune system and allergy | Medical Biochemistry: Proteins And Peptides | Protein Targeting And Signal Transduction

Related Links