Linkage Projects - Grant ID: LP0455508

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0455508

Funding Status
Closed

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Funded Activity Summary

DsbA: A target for the design of drug candidates as selective inhibitors of oxidative protein folding in Gram negative bacteria. There is a clear need for development of novel antibiotics which are capable of treating the increasingly prevalent strains of pathogenic bacteria that are resistant to currently available drugs. In this proposal we will design novel inhibitors of bacterial enzymes that are required for the correct folding of a variety of proteins and test the effects of these molecules on enzyme activity, bacterial growth and antibiotic resistance. Specific inhibitors of these enzymes constitute a novel strategy for the treatment of bacteria that have developed resistance to existing antimicrobial drugs.

Funded Activity Details

Start Date: 01-01-2004

End Date: 31-01-2007

Funding Scheme: Linkage Projects

Funding Amount: $103,905.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences | Biochemistry And Cell Biology Not Elsewhere Classified | Pharmaceutical Sciences And Pharmacy | Characterisation Of Macromolecules

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biological sciences | Characterisation Of Macromolecules | Pharmaceutical Sciences And Pharmacy | Pharmacology and Pharmaceutical Sciences | Treatments (e.g. chemicals, antibiotics)

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