Linkage Projects - Grant ID: LP0455327

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0455327

Funding Status
Closed

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Funded Activity Summary

Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four neuronal cell cultures established with gene-based selection criteria. These cultures will be characterised by gene expression, immunocytochemistry, radiolabelled neurotransmitter release, electrophysiology and Ca2+ imaging studies. This study will highlight the functional effects of gene selection procedures upon stem cell-derived neurons.

Funded Activity Details

Start Date: 28-09-2004

End Date: 30-06-2007

Funding Scheme: Linkage Projects

Funding Amount: $398,733.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurosciences Not Elsewhere Classified | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Animal Physiology—Cell

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Other |

Other Keywords

Animal Physiology—Cell | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Neurosciences Not Elsewhere Classified | Other

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