Linkage Projects - Grant ID: LP0349397

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0349397

Funding Status
Closed

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Funded Activity Summary

Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.

Funded Activity Details

Start Date: 21-10-2003

End Date: 20-10-2006

Funding Scheme: Linkage Projects

Funding Amount: $330,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Diagnostic Applications | Nanotechnology | Nanotechnology | Gene Expression |

ANZSRC Socio-Economic Objective (SEO)

Diagnostics | Biological sciences | Diagnostic methods

Other Keywords

Biological sciences | Diagnostic Applications | Diagnostic methods | Diagnostics | Gene Expression | Nanotechnology

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