Linkage Projects - Grant ID: LP0349227

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0349227

Funding Status
Closed

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Funded Activity Summary

Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)

Funded Activity Details

Start Date: 01-12-2003

End Date: 30-11-2006

Funding Scheme: Linkage Projects

Funding Amount: $69,099.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biomedical Engineering Not Elsewhere Classified | Pharmacology and Pharmaceutical Sciences | Basic Pharmacology | Animal Physiology—Biophysics |

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular system and diseases | Medical instrumentation | Other

Other Keywords

Animal Physiology—Biophysics | Basic Pharmacology | Biomedical Engineering Not Elsewhere Classified | Cardiovascular system and diseases | Medical instrumentation | Other | Pharmacology and Pharmaceutical Sciences

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