Linkage Projects - Grant ID: LP0348732

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0348732

Funding Status
Closed

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Funded Activity Summary

The Development of Computer-Aided Molecular Modelling and Drug Design Techniques for Flexible Enzyme Targets - New Anti-HIV Agents. The dynamic motion of proteins upon binding of small molecules is crucial in many cases for the function of the protein or for the function of drugs acting upon the protein. Current methods in computer-aided design of small molecules binding to proteins do not take this protein flexibility fully into account. This project intends to develop molecular dynamics simulation techniques for this purpose, initially using the HIV reverse transcriptase enzyme as the target protein. The methods developed will, however, be universally applicable. The project further aims to design, synthesise and test novel medicinal agents specifically against drug resistance in HIV.

Funded Activity Details

Start Date: 07-08-2003

End Date: 31-12-2006

Funding Scheme: Linkage Projects

Funding Amount: $188,901.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Theoretical And Computational Chemistry Not Elsewhere Classified | Medicinal and Biomolecular Chemistry | Biological And Medical Chemistry | Organic Chemical Synthesis |

ANZSRC Socio-Economic Objective (SEO)

Infectious diseases | Treatments (e.g. chemicals, antibiotics) | Chemical sciences

Other Keywords

Biological And Medical Chemistry | Chemical sciences | Infectious diseases | Medicinal and Biomolecular Chemistry | Organic Chemical Synthesis | Theoretical And Computational Chemistry Not Elsewhere Classified | Treatments (e.g. chemicals, antibiotics)

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