Linkage Projects - Grant ID: LP0347910

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0347910

Funding Status
Closed

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Funded Activity Summary

Modulation of protein folding pathways: a new platform technology for molecular medicine. Misfolding of proteins is becoming recognised as a major cause of inherited disease. We propose to develop a chemical agent that will optimise the folding of alpha1-antitrypsin (AAT), misfolding of which gives rise to inheritable liver and lung disease. This agent will have potential application as a therapy for sufferers of AAT-misfolding disease and for improving the yield of AAT purified from human plasma, which is the current agent used to treat patients with AAT-misfolding disease.

Funded Activity Details

Start Date: 01-07-2003

End Date: 31-12-2008

Funding Scheme: Linkage Projects

Funding Amount: $225,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biotechnology | Medical Biochemistry: Proteins And Peptides | Biomedical Engineering | Biomaterials

ANZSRC Socio-Economic Objective (SEO)

Respiratory system and diseases (incl. asthma) | Treatments (e.g. chemicals, antibiotics) | Inherited diseases (incl. gene therapy) |

Other Keywords

Biomaterials | Biomedical Engineering | Inherited diseases (incl. gene therapy) | Medical Biochemistry: Proteins And Peptides | Medical Biotechnology | Respiratory system and diseases (incl. asthma) | Treatments (e.g. chemicals, antibiotics)

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