Linkage Projects - Grant ID: LP0347762

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0347762

Funding Status
Closed

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Funded Activity Summary

The role of the Ttyh1 protein in cell activation. We have cloned TTYH1, a human homologue of the Drosophila melanogaster tweety gene. The mouse gene has also been identified. The predicted structure of the protein is a membrane protein with 5 transmembrane domains. We have also expressed a GFP-tagged fusion protein in mouse fibroblasts. Confocal microscopy indicates that this protein is likely to be a novel adhesion molecule, with a cellular distribution characteristic of molecules such as integrins. We aim to determine the function of Ttyh1, its interacting intra- and extra-cellular proteins and to assess its candidature as a molecule of importance in cell migration and adhesion.

Funded Activity Details

Start Date: 07-01-2003

End Date: 31-12-2005

Funding Scheme: Linkage Projects

Funding Amount: $84,099.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

Clinical health not specific to particular organs, diseases and conditions | Biological sciences |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) | Clinical health not specific to particular organs, diseases and conditions | Protein Targeting And Signal Transduction

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